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Laboratory of ultrasonic
electronics,
Doshisha University

Laboratory of Ultrasonic Electronics, Faculty of Life and Medical Sciences, Doshisha University carries out the research works on ultrasonic imaging, bioeffects of ultrasound exposure, and piezoelectric devices.

Information

October 26, 2019
46th Annual Meeting of Kansai Chapter, Japan Society of Ultrasonics in Medicine was held in Osaka Prefecture International Convention Center.
September 5, 2019
Prof. Iwaki Akiyama was elected as Administrative Councilor of World Federation for Ultrasound in Medicine and Biology.
April 2, 2019
The research applied for Kakenhi Basic Resarch (B) was adopted.
April 1, 2019
Prof. Iwaki Akiyama assumed the chairperson of Steering Committee of Kansai Chapter, Japan Society of Ultrasonics in Medicine.

Research

We carry out the research works on Ultrasonic Imaging, Bioeffects of ultrasonic exposure and Piezoelectric devices.

Tissue characterization by using sound velocity change due to ultrasonic heating

While biological tissue becomes cancerous, temperature dependence of sound velocity changes due to cancerous conditions. So it is capable of differential diagnosis of benign or malignant by temperature dependence of sound velocity. It is known that temperature of biological tissue is increased as exposed to ultrasound. Thus ultrasonic measurement of small change of sound velocity of biological tissue as exposed to ultrasound in short time has a potential for ultrasonic tissue characterization. In particular, the patients with fatty liver of growing fibrosis tissue causes cancerous has been increased in recent years. This type of disease is called as nonalcoholic steato-hepatitis (NASH). The aim of this study is to propose and confirm the feasibility of the method for diagnosis of NASH.

Multimodality imaging of MR and US

Ultrasonic probes which is capable of simultaneous use under high magnetic fields environments of MRI has been developed. Because this probe is equipped with MR markers, both of MRI and USI are easily merged and it is capable of producing a multimodality image as shown in the left hand side. US image (upper) MR image (middle) and fusion image (lower) of human neck region. Thyroid region is enhanced as red region in the fusion image.

Member

Iwaki Akiyama , Ph.D

Iwaki Akiyama , Ph.D
Professor of Biomedical Science and Informatics, Director of Medical Ultrasound Research Center, Doshisha University

PROFILE

Ph.D, Executive Trustee, Ultrasonic Engineering Fellow, Chair of Equipments and Safety Committee, Chair of Steering Committee of Kansai Chapter, Japan Society of Ultrasonics in Medicine, Administrative Councilor, World Federation for Ultrasound in Medicine and Biology, Secretary, Chair of Safety Committee, Asian Federation of Societies for Ultrasound in Medicine and Biology, Member of Biomedical Acoustics Committee, Acoustical Society of America

【Major lectures in charge】
Electronics, Experiments of Biomedical Informatics, Electronic Measurement, Advanced Lecture of Medical Imaging System, Advanced Lecture of Medical Ultrasound, Advanced Lecture of Ultrasonic Electronics
【Major research experience】
1985〜1995 ultrasonic harmonic imaging at Shonan Institute of Technology
1993〜1994 ground penetrating radar, at University of California Santa Barbara
1995〜2007 ultra-broadband ultrasonic imaging at Shonan Institute of Technology
2002〜2006 MEXT Special Project for Earthquake Disaster Mitigation in Urban Areas, “Development of Rescue Radar”
2006〜2008 Research Fund of Fire and Disaster Management Agency “Detection of survivor buried in rubble by rescue radar”
2007 Chair of Organizing Committee, 29th International Symposium on Acoustical Imaging(Kanagawa Prefecture Shonan International Village Center)
2012~ present  Bioeffect of ultrasonic exposure
2013〜2017 MEXT Supported Program for the Strategic Research Foundation at Private Universities, “Developmental Base Formation of Novel Medical Technology based on Ultrasound”

Iwaki Akiyama , Ph.D

Shinji Takayanagi, Ph.D
Assistant Professor of Department of Biomedical Information, Faculty of Life and Medical Sciences. Researcher of Medical Ultrasound Research Center, Doshisha University.

PROFILE

Ph. D. in Engineering.
Member of Steering Committee of Piezoelectric Materials & Devices Symposium.

【Major lectures in charge】
Electronics, Programming, Electromagnetism, Medical Information Experiments
【Major research experience】
2008~present Crystalline-Orientation Control of Piezoelectric Films by Sputtering Deposition.
2012~2013 JSPS Research Fellow (DC2)
2011~present Shear-Mode FBAR Sensor for Detection of Antigen-Antibody Reaction
2012~present SH-SAW sensor for Detection of Liquid Properties
2014~2015 MEXT Project for N.R.P. in Nanotech CUPAL
2019〜present Bioeffect of Ultrasonic Exposure

Graduate Students

2nd Grade, Master Course

  • Ge De
  • Kouki Hasegawa
  • Tatsuya Kawaguchi
  • Naoki Kawahara
  • Takashi Kosaka
  • Yuusaku Maeda
  • Hiroto Nakahara
  • Haruka Shimada
  • Takumi Tominaga
  • Mao Watabe

1st Grade, Master Course

  • Shouta Kadowaki
  • Azusa Kitera
  • Takahiro Uechi
  • Kei Ueno
  • Koudai Yamagami

Under Graduate (Senior)

  • Yurie Fukuda
  • Yukitada Gonno
  • Rin Horii
  • Ryouma Kagami
  • Jin Kashimoto
  • Reiji Kayamoto
  • Izumi Kuze
  • Taiki Matsukawa
  • Kei Matsumoto
  • Yoshiki Matsuyama
  • Yoshinori Nakajima
  • Mayu Nishida
  • Akane Nishiguchi
  • Yuuki Nishiyama
  • Masayuki Ootani
  • Isami Sakamoto
  • Kouki Takahashi
  • Naoki Toda
  • Shuuta Tomimatsu
  • Naoki Tomiyama
  • Souya Tsujimoto
  • Yuuya Ueki

Support Staff

  • Eri Yasui

Achivements

Original Article

Yukako Tsujimoto, Daiki Matsuda, Kiyoyuki Minamiguchi, Toshihiro Tanaka, Toshiko Hirai, Iwaki Akiyama, Measurement of temperature dependence of sound velocity in biological tissues, Japanese Journal of Applied Physics, Vol.58, SGGE01, 2019

Yukako Tsujimoto, Mai Morimoto, Naotaka Nitta, Iwaki Akiyama , Ultrasonic measurement of sound velocity fluctuations in biological tissue due to ultrasonic heating and estimation of thermo-physical properties, Journal of Medical Ultrasonics, Vol.46, pp 35–43, 2019

Ken Inagaki, Shimpei Arai, Kengo Namekawa, Iwaki Akiyama, Sound velocity estimation and beamform correction by simultaneous multimodality imaging with ultrasound and magnetic resonance, Applied Sciences (Switzerland), Vol.8, pp. 2133, 2018

Teruhisa Okuya, Teruhisa Okuya, Toshihiko Date, Miwa Fukino, Mikio Iwakawa, Kohji Sasabe, Kumi Nagao, Yuki Moriizumi, Iwaki Akiyama, Yoshiaki Watanabe , Investigating the type and strength of emotion with music: An fMRI study, Acoustical Science and Technology, Vol.38, pp.120-127, 2017

Keisuke Imade, Takashi Kageyama, Daisuke Koyama, Yoshiaki Watanabe, Kentaro Nakamura, Iwaki Akiyama, Measurement of sound pressure and temperature in tissue-mimicking material using an optical fiber Bragg grating sensor, Journal of Medical Ultrasonics, Vol.43, pp.473-479, 2016

Noriya Takayama, Yasunao Ishiguro, Nobuyuki Taniguchi, Kazuki Akai, Hideki Sasanuma, Yoshikazu Yasuda, Naotaka Nitta, Iwaki Akiyama , The effect of ultrasound with acoustic radiation force on rabbit lung tissue: a preliminary study, Journal of Medical Ultrasonics, Vol.43, pp.481-483, 2016

Yasunao Ishiguro , Naotaka Nitta, Nobuyuki Taniguchi, Kazuki Akai, Noriya Takakayama, Hideki Sasanuma, Yukiyo Ogata, Yoshikazu Yasuda, Iwaki Akiyama , Ultrasound exposure (mechanical index 1.8) with acoustic radiation force impulse evokes extrasystolic waves in rabbit heart under concomitant administration of an ultrasound contrast agent, Journal of Medical Ultrasonics, Vol.43,pp.3-7, 2016

Yasunao Ishiguro, Hideki Sasanuma, Naotaka Nitta, Nobuyuki Taniguchi, Yukiyo Takano, Yoshikazu Yasuda, Iwaki Akiyama , The arrhythmogenetic effect of ultrasonic exposure with acoustic radiation force (ARF) impulse on the rabbit heart with ultrasound contrast agent; erfluorobutane., Journal of Medical Ultrasonics, 42, pp.47-50, 2015

Naotaka Nitta, Yasunao Ishiguro, Hideki Sasanuma, Nobuyuki Taniguchi, Iwaki Akiyama, Experimental System for In-Situ Measurement of Temperature Rise in Animal Tissue under Exposure to Acoustic Radiation Force Impulse, Journal of Medical Ultrasonics, 42, pp. 39-46, 2015

G.R.T.Haar, J.S.Abramowicz, I.Akiyama, D.H.Evans,M.C.Ziskin,K.Marsal, Do we need to restrict the use of doppler ultrasound in the first trimester of pregnancy?, Ultrasound in Medicine and Biology, Vol.39, pp. 374-380, 2013

International Presentation

AKIYAMA IwakiBioeffects of ultrasound with long pulse duration during administration of contrast agentsWorld Federation for Ultrasound in Medicine and Biology(Invited)

AKIYAMA IwakiMeasurement of sound velocity change due to ultrasonic heatingWorld Federation for Ultrasound in Medicine and Biology (Invited)

TSUJIMOTO Yukako, AKIYAMA Iwaki, Estimation of the thermo-physical property of biological tissues from temperature rise due to ultrasound exposure., Acoustical Society of America

AKIYAMA Iwaki, Simultaneous Ultrasonic Imaging under Magnetic Resonance Imaging, 13th Congress of Asian Federation of Societies for Ultrasound in Medicine and Biology(Invited)

TAKAYAMA Noriya, SASANUMA Hideki, RIFU Kazuma, FURUYA M, LEFOR K, AKIYAMA Iwaki, TANIGUCHI Nobuyuki, Lung Hemorrhage induced by acoustic radiation force impulse elastography:A preliminary study in rabbits, EUROSON 2018

Yukako Tsujimoto Mai Morimoto, Naotaka Nitta, Iwaki Akiyama, Measurement of thermal properties of the biological tissues by ultrasonic heatingArtimino Conference

AKIYAMA IwakiEffect on Rabbit Heart Exposure to Ultrasound with Long Pulse DurationInternational Congress on Ultrasonics(Invited)

M. Morimoto, Y. Tsujimoto, I. Akiyama, Proposal of Ultrasonic Imaging of thermophysical property distribution in vivo by ultrasonic heatingAcoustical Society of America

M. Sugiyama, H. Kanayama, I. AkiyamaMeasurement of volumetric heat capacity of biological tissues heated by ultrasound exposure,Acoustical Society of America

KIHARA Ayane, KANAI Kazumasa, AKIYAMA IwakiUltrasonic imaging of sum frequency components by crossed beam contrast echo method.Acoustical Society of America

AKIYAMA IwakiSafety of Medical UltrasoundAsian Symposium on Advanced Ultrasound Technology(Invited)

AKIYAMA IwakiOn the thermal effect in biological tissues exposed to ultrasound of longer pulse duration after administration of contrast agentsIEEE International Ultrasonics Symposium

AKIYAMA IwakiSimultaneous measurement of sound pressure and temperature of tissue mimicking material by an optical fiber Brag grating sensor,Acoustical Society of America

Notaka Nitta, Yasunao Ishiguro,Hideki Sasanuma, Nobuyuki Taniguchi and IswaidssssIn vivo measurement of temperature rise living rabbit's liver exposed to ultrasound with acoustic radiation forceProceedings of IEEE International Ultrasonics Symposium

AKIYAMA Iwaki, Biological effects of tissue exposed to ultrasound with acoustic radiation forceThe 11th Congress of the Asian Federation of Societies for Ultrasound in Medicine and Biology(Invited)

AKIYAMA IwakiMeasurement of temperature rise of tissue heating by ultrasonic pulse-echo methodThe 11th Congress of Asian Federation of Societies for Ultrasound in Medicine and Biology(Invited)